METABOLITES OF 1 l - DEHYDROCORTICOSTERONE : PREGNANE

A study’ which involved the administration of relatively large amounts of synthetic 11-dehydrocorticosterone (Ia) and its acetate2 (Ib) to a woman (Case 1) and to a man (Case 2) with Addison’s disease afforded an opportunity to determine what urinary products might be related to this hormone, Thus far it has not been possible to isolate from the urine, in cases of hyperfunctioning lesions of the adrenal cortex, any 11-oxygenated pregnane derivatives. In the present study pregnane-3(cu) ,20-diol-1 l-one and another unidentified compound were isolated from the urine collected while ll-dehydrocorticosterone and its acetate were being given. These compounds could not be found in t)he urine during another period when 17-hydroxy-11-dehydrocorticosterone was being given.